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Related Concept Videos

Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
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Published on: March 29, 2019

The acellular matrix (ACM) for bladder tissue engineering: A quantitative magnetic resonance imaging study.

Hai-Ling Margaret Cheng1, Yasir Loai, Marine Beaumont

  • 1Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. hai-ling.cheng@sickkids.ca

Magnetic Resonance in Medicine
|July 29, 2010
PubMed
Summary

Quantitative MRI effectively characterizes bladder acellular matrices (ACMs) and their modifications. This noninvasive technique monitors scaffold properties and cell interactions, aiding tissue engineering and organ regeneration strategies.

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Medical Imaging

Background:

  • Bladder acellular matrices (ACMs) are promising scaffolds for tissue engineering due to their native biomechanical and biological properties.
  • Conventional scaffolds often lack the complex structure and function of native tissues.
  • Noninvasive methods for characterizing ACMs and monitoring cellular interactions are needed to optimize their use.

Purpose of the Study:

  • To evaluate quantitative magnetic resonance imaging (MRI) for characterizing bladder ACMs.
  • To investigate the effects of incorporating hyaluronic acid on ACM properties using MRI.
  • To assess MRI's potential for guiding ACM-based tissue engineering strategies.

Main Methods:

  • Quantitative MRI measurements, including T(1), T(2) relaxation times, and diffusion coefficient, were performed on bladder ACMs.
  • ACMs with and without incorporated hyaluronic acid were analyzed.
  • Biochemical assays were used to measure water uptake and glycosaminoglycan content for correlation with MRI data.

Main Results:

  • Quantitative MRI parameters (T(1), T(2), diffusion coefficient) correlated with biochemical findings of increased water uptake and glycosaminoglycan content in hyaluronic acid-modified ACMs.
  • Multicomponent MRI provided specific insights: diffusion data indicated an acellular environment, while T(2) components differentiated the effects of glycosaminoglycans and hydration.
  • MRI results demonstrated consistency with biochemical analyses, validating its utility.

Conclusions:

  • Quantitative MRI is a valuable noninvasive tool for characterizing bladder ACM composition and structure.
  • MRI can effectively monitor the impact of incorporating biomaterials like hyaluronic acid into ACMs.
  • This approach can guide the development of improved ACM scaffolds for organ regeneration.