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Updated: Jun 10, 2026

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases
Published on: December 6, 2016
Stereological investigation of age-related changes of the capillaries in white matter
Wei-Hua Shao1, Chen Li, Lin Chen
1Department of Histology and Embryology, Chongqing Medical University, Chongqing, People's Republic of China.
Abstract:
We, for the first time, investigated the age-related changes of the capillaries in white matter using immunohistochemistry and stereological techniques. Ten young female (7 months) and 10 aged female (27 months) rats were used. The total length, total volume, and total surface area of the capillaries in white matter of aged rats were all significantly lower than those of young rats. The age-related changes of the capillaries in white matter may have important implications for age-related white matter atrophy and age-related cognitive impairments.
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