Improved pharmacokinetics of AMG 517 through co-crystallization. Part 1: comparison of two acids with corresponding

Mary K Stanton1, Ron C Kelly, Adria Colletti

  • 1Amgen, Inc., 360 Binney Street, Cambridge, Massachusetts 02142, USA. mstanton@amgen.com

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Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
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Acid Halides to Amides: Aminolysis

Aminolysis is a nucleophilic acyl substitution reaction, where ammonia or amines act as nucleophiles to give the substitution product. Acid halides react with ammonia, primary amines, and secondary amines to yield primary, secondary, and tertiary amides, respectively.
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Amines to Amides: Acylation of Amines01:19

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