[Experimental and clinical aspects of chemotherapeutic agents on Salmonella gastroenteritis]

The experimental and clinical aspects such as difficulties in eradicating Salmonella, intracellular facultative bacteria, causing gastroenteritis were investigated. 1. In vitro study: In the present study using human polymorphonuclear neutrophilic leucocytes (PMNs), the author evaluated the eradicating effects of various drugs on Salmonella which can not be killed usually within PMNs. The author inferred that the phagocytic action was enhanced by fosfomycin (FOM); the transport of FOM to PMNs contributes greatly to the enhancement of the eradicating effects of FOM on Salmonella. This finding has been further supported by the morphological changes in the Salmonella in PMNs which were examined by electron microscopy. Further it was confirmed that various chemotherapeutic agents were affected by beta-lactamase in the feces. 2. Clinical Study: Some drugs were used for the treatment of Salmonella gastroenteritis to investigate the relationship between the drugs and eradication of the bacteria. The first was treated with FOM for 5 days after treatment with the other drugs for 5 days, the second was treated with FOM initially, and third was treated with the other drugs. The treatment in the first group was the most useful and the eradication rate of the bacteria was significantly high.