[Brain imaging and pathology in children with neurological diseases]

Morphological and functional imaging of the brain is rapidly developing, while knowledge of brain pathology is also progressing at the levels of protein and RNA along with molecular biology. In this review, brain imaging and pathology were compared developmentally. Brain imaging reveals the early stages and progression of brain damage, and the pathology confirms the characteristics of the lesions. However, some pathological lesions such as pontosubicular neuron necrosis (death) cannot be diagnosed by brain imaging. Further accumulation of brain images and pathological tissues may be helpful to clarify the pathogenesis and effective preventive strategies.