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Updated: Dec 17, 2025

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
Published on: November 21, 2013
[Current perspective on the pathogenesis of schizophrenia from the viewpoint of risk factors such as DISC1
Kozo Kaibuchi1, Daisuke Tsuboi
1Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa-ku, Nagoya, 466-8550 Japan. kaibuchi@med.nagoya-u.ac.jp
Abstract:
The onset of schizophrenia symptoms typically occurs in young adulthood. It most commonly manifests as hallucinations, paranoid or bizarre delusions, or disorganized speech and thinking. Schizophrenia is often accompanied by social or occupational dysfunction. Recent genetic studies revealed several probable susceptibility genes for schizophrenia such as Neuregulin1, Dysbindin and Disrupted-in-Schizophrenia-1 (DISC1). DISC1 was originally identified as the sole gene that associated with a high inheritance of schizophrenia and other psychiatric illnesses in a large Scottish family. We here review the recent advance in understanding of pathophysiological functions of DISC1. [corrected]
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