Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

Storage

Storage

A schema is a mental framework that helps individuals organize and interpret information. Schemata, formed from previous experiences, influence how we process new information: how we encode it, the inferences we make, and how we retrieve it. For instance, a schema for what a typical classroom looks like might include desks, a teacher's desk, a whiteboard, and students in such an environment. This expectation helps us quickly understand and navigate new classrooms without needing to analyze each...

Functional Brain Systems: Limbic System

Functional Brain Systems: Limbic System

The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Affect Labeling and Reappraisal as an Emotion Regulation Strategy.

Affective science·2026

Same author

Different brain regions support deliberation during food choice in disordered and healthy eating.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026

Same author

The costs and rewards of men's romantic dependence: A gendered perspective.

The Behavioral and brain sciences·2026

Same author

Learning reinforces curiosity for related information.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

Human exploration strategically balances approaching and avoiding uncertainty.

eLife·2026

Same author

The role of mindfulness in attenuating the adverse effects of daily negative events: An experience sampling study.

Emotion (Washington, D.C.)·2026

Search research articles

Related Experiment Video

Updated: Jun 10, 2026

Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice

Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice

Published on: April 3, 2021

Cooperation between the hippocampus and the striatum during episodic encoding.

Talya Sadeh¹, Daphna Shohamy, Dana Rubi Levy

¹Department of Psychology, Tel Aviv University, Ramat Aviv, Israel.

Journal of Cognitive Neuroscience

|July 30, 2010

Summary

The hippocampus and striatum cooperate for episodic memory. This study shows their interaction during memory encoding is crucial for successful long-term memory formation.

More Related Videos

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

Related Experiment Videos

Last Updated: Jun 10, 2026

Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice

Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice

Published on: April 3, 2021

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

Area of Science:

Neuroscience
Cognitive Psychology

Background:

The hippocampus and striatum are traditionally viewed as supporting independent memory systems.
Their interaction in forming long-term episodic memories remains poorly understood.

Purpose of the Study:

To investigate the cooperative interaction between the hippocampus and striatum in episodic memory formation.
To determine if the striatum contributes to episodic memory beyond implicit or habitual learning.

Main Methods:

Functional magnetic resonance imaging (fMRI) was used to monitor brain activity during a memory encoding task.
Participants underwent fMRI scanning while encoding items and were later tested on their memory recall.

Main Results:

Successful memory encoding was linked to increased activity in both the hippocampus and the striatum (putamen).
Correlations in activity between the hippocampus and striatum were observed for remembered items, but not forgotten ones.
The strength of hippocampal-striatal correlation predicted individual memory success.

Conclusions:

The findings provide novel evidence for the cooperative role of the hippocampus and striatum in episodic memory encoding.
This study demonstrates that the striatum actively contributes to long-term episodic memory, challenging previous assumptions.