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Monozygotic twins with idiopathic internal root resorption: A case report
11st Department of Stomatology, Faculty of Medicine, Pavol Jozef Safarik University, Kosice, Slovakia. danielurban@me.com
Summary
This study reports the first instance of internal root resorption in identical twins, suggesting a genetic predisposition. The findings highlight the role of interleukin-1 gene variations in this dental condition.
Area of Science:
- Dentistry
- Genetics
- Oral Pathology
Background:
- Genetic factors are increasingly recognized in the etiology of root resorption.
- Previous research has linked interleukin (IL)-1 gene polymorphism to external root resorption.
- The specific role of genetic predisposition in internal root resorption remains less understood.
Observation:
- A rare case of internal root resorption was diagnosed in the upper left central incisor of healthy 17-year-old Caucasian monozygotic twins.
- Neither twin had a history of orofacial trauma or orthodontic treatment.
- The condition was idiopathic, with no other known causative factors identified.
Findings:
- The presence of the IL-1beta+C3953 allele, associated with IL-1RN mutation, indicates a susceptibility to exaggerated inflammatory responses.
- This genetic profile is considered a significant risk factor for pathological resorption.
- The identical genetic makeup of the twins supports a hereditary component in internal root resorption.
Implications:
- This case underscores the potential genetic basis for internal root resorption.
- Further research into IL-1 gene polymorphisms may elucidate mechanisms and inform preventative strategies.
- Understanding genetic predispositions could lead to personalized dental treatments for root resorption.
