Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammation01:38

Inflammation

Overview
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Hypodermis01:02

Hypodermis

The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
Cross-bridge Cycle01:26

Cross-bridge Cycle

As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Elevated IL-4 and IL-13 Expression in Hailey-Hailey Disease: Evidence for Th2-Mediated Pathogenesis and Targeted Treatment.

Journal of cutaneous pathology·2026
Same author

Histopathologic Spectrum of Scleromyxedema: Classic and Granulomatous Patterns With Emphasis on Eosinophilic Infiltrates and Eccrine Gland Proliferation as Diagnostic Masqueraders.

The American Journal of dermatopathology·2026
Same author

Aryl Hydrocarbon Receptor Expression in Cutaneous Lupus: A Clinicopathologic Correlation.

The American Journal of dermatopathology·2026
Same author

Vascular Proliferation in Biopsies from Active Lichen Planopilaris as a Novel Pathologic Finding.

The American Journal of dermatopathology·2026
Same author

Comorbidity Burden and Biologic Access in an Uninsured Psoriasis Population: A 20-Year Descriptive Study.

International journal of dermatology·2026
Same author

Equitable access to biologic therapies in a psoriasis safety-net clinic: A retrospective cohort study.

Clinics in dermatology·2025

Related Experiment Video

Updated: Jun 10, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Lipodermatosclerosis.

Maria Miteva1, Paolo Romanelli, Robert S Kirsner

  • 1Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.

Dermatologic Therapy
|July 30, 2010
PubMed
Summary
This summary is machine-generated.

Lipodermatosclerosis (LDS) is a chronic inflammatory skin condition often linked to venous insufficiency. Acute LDS presents with severe pain, making compression therapy difficult; fibrinolytic therapy is suggested until compression is tolerated.

More Related Videos

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

Related Experiment Videos

Last Updated: Jun 10, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

Area of Science:

  • Dermatology
  • Vascular Medicine

Background:

  • Lipodermatosclerosis (LDS) is a chronic inflammatory condition affecting the lower legs.
  • It is characterized by skin induration and hyperpigmentation, often presenting an "inverted champagne bottle" appearance.
  • LDS is commonly associated with chronic venous insufficiency and predominantly affects middle-aged women.

Purpose of the Study:

  • To differentiate between chronic and acute forms of lipodermatosclerosis.
  • To discuss the diagnostic challenges of acute LDS, which is often misdiagnosed.
  • To outline treatment strategies for both chronic and acute lipodermatosclerosis.

Main Methods:

  • Clinical presentation analysis of lipodermatosclerosis.
  • Review of diagnostic criteria for acute and chronic forms.
  • Evaluation of treatment modalities including compression therapy and fibrinolytic agents.

Main Results:

  • Chronic LDS typically shows induration and hyperpigmentation.
  • Acute LDS is defined by severe pain and can be mistaken for other inflammatory conditions.
  • Compression therapy is the primary treatment for chronic LDS when tolerated.

Conclusions:

  • Acute lipodermatosclerosis presents with significant pain, often precluding immediate use of compression therapy.
  • Fibrinolytic therapy is recommended for acute LDS when pain prevents compression.
  • Successful management of LDS requires tailored treatment based on the clinical presentation.