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Related Experiment Video

Updated: Jun 10, 2026

Laser Capture Microdissection of Glioma Subregions for Spatial and Molecular Characterization of Intratumoral Heterogeneity, Oncostreams, and Invasion
09:09

Laser Capture Microdissection of Glioma Subregions for Spatial and Molecular Characterization of Intratumoral Heterogeneity, Oncostreams, and Invasion

Published on: April 12, 2020

Lipidized glioblastoma: a rare differentiation pattern.

Kirti Gupta1, Ivreet Kalra, Pravin Salunke

  • 1Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India. kirtigupta10@yahoo.co.in

Neuropathology : Official Journal of the Japanese Society of Neuropathology
|July 30, 2010
PubMed
Summary

This study details a rare case of lipidized glioblastoma, a brain tumor with unusual lipid accumulation. The findings contribute to understanding this rare variant of glioblastoma.

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Area of Science:

  • Neuro-oncology
  • Pathology
  • Cell Biology

Background:

  • Glioblastoma is an aggressive primary brain tumor.
  • Lipid accumulation is an uncommon feature in glioblastoma.
  • Understanding tumor variants aids in diagnosis and treatment.

Observation:

  • A rare case of lipidized glioblastoma occurred in a 65-year-old woman's tempo-parietal lobe.
  • The tumor consisted of diffuse sheets of lipidized cells with xanthomatous cytoplasm (60% of mass).
  • Immunohistochemistry showed glial fibrillary acidic protein (GFAP) positivity.

Findings:

  • Lipidized glioblastoma is an extremely rare differentiation pattern.
  • Ultrastructural analysis confirmed significant lipid accumulation within tumor cells.

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Related Experiment Videos

Last Updated: Jun 10, 2026

Laser Capture Microdissection of Glioma Subregions for Spatial and Molecular Characterization of Intratumoral Heterogeneity, Oncostreams, and Invasion
09:09

Laser Capture Microdissection of Glioma Subregions for Spatial and Molecular Characterization of Intratumoral Heterogeneity, Oncostreams, and Invasion

Published on: April 12, 2020

Co-culture of Glioblastoma Stem-like Cells on Patterned Neurons to Study Migration and Cellular Interactions
10:08

Co-culture of Glioblastoma Stem-like Cells on Patterned Neurons to Study Migration and Cellular Interactions

Published on: February 24, 2021

On-Site Sampling and Extraction of Brain Tumors for Metabolomics and Lipidomics Analysis
06:48

On-Site Sampling and Extraction of Brain Tumors for Metabolomics and Lipidomics Analysis

Published on: May 31, 2020

  • Glial fibrillary acidic protein (GFAP) expression indicates glial origin.

    • Implications:

    • This case expands the histopathological spectrum of glioblastoma.
    • Adds valuable observational data to the literature on lipid accumulation in brain tumors.
    • May inform future research into the mechanisms of lipidization in glioblastoma.