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Updated: Jun 10, 2026
Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
Published on: July 28, 2013
Diffusion tensor imaging in neuropsychiatric systemic lupus erythematosus
Rex E Jung1, Arvind Caprihan, Robert S Chavez
1The Mind Research Network, Albuquerque, New Mexico 87106, USA. rjung@mrn.org
Background:
Neuropsychiatric systemic lupus erythematosus (NPSLE) is associated with increased morbidity and mortality.
Methods:
We used Diffusion Tensor Imaging (DTI) to assess white matter abnormalities in seventeen NPSLE patients, sixteen SLE patients without NPSLE, and twenty age- and gender-matched controls.
Results:
NPSLE patients differed significantly from SLE and control patients in white matter integrity of the body of the corpus callosum, the left arm of the forceps major and the left anterior corona radiata.
Conclusions:
Several possible mechanisms of white matter injury are explored, including vascular injury, medication effects, and platelet or fibrin macro- or microembolism from Libman-Sacks endocarditis.
