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Cimetidine and ranitidine may not cross-react to cause thrombocytopenia
1Department of Medicine, Hadassah University Hospital Mount Scopus, Jerusalem, Israel.
Journal of Internal Medicine
|July 1, 1991
Abstract:
We report the case of a patient with peptic ulcer disease who developed cimetidine-induced thrombocytopenia. The thrombocytopenia resolved spontaneously following discontinuation of cimetidine, and did not recur with ranitidine. We concluded that cimetidine and ranitidine do not necessarily cross-react to induce thrombocytopenia. Thus the exclusion of both H2-blockers in the event that one has caused thrombocytopenia may not be justified.
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