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Updated: Jun 10, 2026
08:31
Kinematic Analysis of Cell Division and Expansion: Quantifying the Cellular Basis of Growth and Sampling Developmental Zones in Zea mays Leaves
Published on: December 2, 2016
Growth and division--not a one-way road
Alexi I Goranov1, Angelika Amon
1David H. Koch Institute for Integrative Cancer Research and Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17-233, 40 Ames Street, Cambridge, MA 02139, USA.
Current Opinion in Cell Biology
|July 30, 2010
Summary
Organisms maintain cell size homeostasis through the interplay of growth and cell division. This review explores how cell cycle progression influences growth, revealing that cyclin-dependent kinases may inhibit growth.
Area of Science:
- Cell Biology
- Molecular Biology
- Biophysics
Background:
- Cell size homeostasis is crucial for organismal function.
- The relationship between cell growth and cell cycle progression is complex.
- While growth's effect on division is known, the impact of cell cycle on growth is less understood.
Purpose of the Study:
- To review recent advances in understanding how cell cycle progression affects cell growth.
- To highlight the dynamic nature of growth during the cell cycle.
- To explore the potential inhibitory role of cyclin-dependent kinases (CDKs) in cell growth.
Main Methods:
- Literature review of recent research findings.
- Synthesis of studies examining cell cycle regulation and cell growth.
- Analysis of experimental evidence on the interplay between proliferation and mass accumulation.
Main Results:
- Cell growth is not constant throughout the cell cycle.
- Evidence suggests that cell cycle progression can modulate growth rates.
- Cyclin-dependent kinases (CDKs) emerge as potential inhibitors of cell growth.
Conclusions:
- Cell cycle progression actively influences cell growth, challenging the notion of constant growth.
- CDKs represent a novel regulatory point impacting cell size control.
- Further research is needed to fully elucidate the mechanisms by which cell cycle machinery regulates growth.
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