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Risk factors associated with urinary albumin excretion in African Americans
K E Ussai1, S W Keith, E Pequignot
1Division of Nephrology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Journal of Human Hypertension
|July 30, 2010
Summary
In young African Americans, elevated blood pressure (BP) is linked to urinary albumin excretion (UAE), even below microalbuminuria thresholds. Other factors like obesity or diabetes showed no significant association with UAE in this cohort.
Area of Science:
- Nephrology
- Cardiovascular Medicine
- Public Health
Background:
- Microalbuminuria is a key indicator of increased cardiovascular event risk.
- Urinary albumin excretion (UAE) is influenced by various cardiovascular risk factors.
- Understanding these factors is crucial for early cardiovascular disease detection, especially in at-risk populations.
Purpose of the Study:
- To investigate cardiovascular risk factors, including inflammatory cytokines, associated with urinary albumin excretion (UAE).
- To examine these associations in a cross-sectional study of African Americans aged 18-49 years.
- To determine if factors like obesity, metabolic parameters, or inflammatory cytokines contribute to UAE in this demographic.
Main Methods:
- Cross-sectional study design involving 488 African American participants (aged 18-49).
- Measurements included overnight urine collection for UAE, blood pressure (BP), BMI, glucose, lipids, insulin, and inflammatory cytokines.
- Statistical analysis utilized log transformation for non-normally distributed variables and multiple linear regressions.
Main Results:
- Log UAE showed a significant correlation with systolic blood pressure (SBP).
- Higher SBP and diastolic BP were significantly different across UAE strata.
- No significant associations were found between UAE and obesity, metabolic parameters, insulin resistance, or inflammatory cytokines.
Conclusions:
- Systolic blood pressure is significantly associated with urinary albumin excretion in young, seemingly healthy African Americans, even below microalbuminuria levels.
- High blood pressure appears to be a primary driver of UAE in this population, independent of obesity or diabetes.
- Further research is needed to elucidate the mechanisms linking BP and UAE in younger, diverse populations.
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