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Updated: Jun 10, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
Published on: March 14, 2025
Obsessive compulsive disorder and dissociation - comparison with healthy controls
Jan Prasko1, Michal Raszka, Tomas Diveky
1Department of Psychiatry, University Palacky and University Hospital, Olomouc, Czech Republic. prasko@fnol.cz
Obsessive compulsive disorder (OCD) patients show lower dissociation levels than healthy individuals. Dissociation intensity correlates with anxiety, depression, and OCD symptom severity in patients.
Area of Science:
- Psychiatry
- Clinical Psychology
- Neuroscience
Background:
- Obsessive compulsive disorder (OCD) is a debilitating mental health condition.
- The role of psychological dissociation in OCD is not fully understood.
- Previous research has not consistently compared dissociation levels between OCD patients and healthy controls.
Purpose of the Study:
- To investigate the relationship between psychological dissociation and psychopathology in OCD patients.
- To compare dissociation levels in individuals with OCD versus healthy controls.
- To determine if dissociation influences the intensity of anxiety, depression, and OCD symptoms.
Main Methods:
- Fifty-five OCD patients and 123 healthy controls were recruited.
- Psychiatric assessment and diagnosis using ICD-10 criteria and the MINI structured interview.
- Validated scales were used: Beck Anxiety Inventory, Beck Depression Inventory, Yale Brown Obsessive Compulsive Scale, and Dissociative Experiences Scale (DES).
Main Results:
- Dissociative Experiences Scale (DES) scores significantly correlated with anxiety (p<0.0001), depression (p<0.0001), and obsessive-compulsive symptom severity (p<0.005).
- OCD patients exhibited significantly lower mean DES scores compared to healthy controls (p<0.0001).
Conclusions:
- Psychological dissociation levels are lower in OCD patients than in healthy individuals.
- Dissociation is associated with the severity of anxiety, depression, and obsessive-compulsive symptoms in OCD.
- Findings suggest dissociation may play a complex role in the manifestation of psychopathology in OCD.
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