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Isolation of Intact Eyeball to Obtain Integral Ocular Surface Tissue for Histological Examination and Immunohistochemistry

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Published on: October 20, 2019

Eyelid closure at death.

¹Department of Palliative Care, Nurse Maude Hospice, 15 Mansfield Avenue, Christchurch, New Zealand.

Indian Journal of Palliative Care

|July 30, 2010

Summary

Most patients (63%) experienced full eyelid closure at death. However, 37% exhibited bilateral ptosis, indicating incomplete eye closure, with neurological and hepatic conditions as potential risk factors.

Area of Science:

Neurology
Gerontology
Palliative Care

Background:

Eyelid closure at death is a common observation.
The etiology of incomplete eyelid closure (ptosis) at death is not fully understood.
Previous research has not extensively explored pre-mortem risk factors for ptosis.

Purpose of the Study:

To determine the incidence of full or partial eyelid closure in hospice patients at the time of death.
To identify potential pre-mortem clinical factors associated with incomplete eye closure.

Main Methods:

A prospective observational study was conducted.
100 consecutive hospice patients were included.
The presence and degree of ptosis were systematically recorded.

Keywords:

Cancer Death Eyelid closure Organicity Ptosis

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Main Results:

A majority of patients (63%) died with their eyes fully closed.
37% of patients presented with bilateral ptosis, indicating incomplete eye closure.
Central nervous system tumor involvement and acute hepatic encephalopathy were identified as potential pre-mortem risk factors for ptosis.

Conclusions:

The findings suggest that organicity, rather than psychogenicity, is the likely cause of failure of full eyelid closure at death.
Neurological and hepatic conditions may play a significant role in the development of ptosis in end-of-life care.
Further research is warranted to elucidate the precise mechanisms underlying ptosis at death.