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Hypercalciuria in children severely affected with osteogenesis imperfecta
A Chines1, D J Petersen, F W Schranck
1Metabolic Research Unit, Shriners Hospital for Crippled Children, St. Louis, MO 63131.
The Journal of Pediatrics
|July 1, 1991
Summary
Hypercalciuria, or high urinary calcium, is common in children with osteogenesis imperfecta. Its severity correlates with the skeletal disorder
Area of Science:
- Pediatric Nephrology
- Pediatric Endocrinology
- Skeletal Dysplasias
Background:
- Osteogenesis imperfecta (OI) is a genetic disorder characterized by brittle bones.
- Hypercalciuria is a condition of elevated calcium levels in the urine.
- The prevalence and significance of hypercalciuria in pediatric OI patients are not well-established.
Purpose of the Study:
- To determine the frequency of hypercalciuria in children with osteogenesis imperfecta.
- To investigate the relationship between hypercalciuria and disease severity in pediatric OI.
Main Methods:
- Retrospective analysis of pediatric patients with osteogenesis imperfecta.
- Evaluation of mineral homeostasis, including urinary calcium levels.
- Assessment of bone mineral density and histomorphometric bone parameters.
Main Results:
- Hypercalciuria was identified in 36% of pediatric OI patients.
- Hypercalciuric children were shorter and had a higher lifelong fracture rate.
- Urinary calcium levels negatively correlated with height z-scores in hypercalciuric patients.
Conclusions:
- Hypercalciuria is a frequent finding in children with osteogenesis imperfecta.
- The degree of hypercalciuria appears to be associated with the severity of osteogenesis imperfecta.
- Further research is warranted to explore the clinical implications of hypercalciuria in pediatric OI.