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Anti-hypertensive drugs have different effects on ventricular hypertrophy regression

Celso Ferreira Filho1, Luiz Carlos de Abreu, Vitor E Valenti

  • 1Departamento de Clínica Médica, Faculdade de Medicina do ABC, Santo André/SP, Brasil. celsoferreira.dmed@epm.br

Clinics (Sao Paulo, Brazil)
|July 30, 2010
PubMed

Insights

Anti-hypertensive drugs can reduce left ventricular hypertrophy (LVH), a condition linked to increased mortality. Different medications showed varying effectiveness in regression, offering insights into cardiovascular disease management.

Area of Science:

  • Cardiology
  • Pharmacology
  • Internal Medicine

Background:

  • Left ventricular hypertrophy (LVH) is associated with increased mortality risk.
  • Regression of LVH correlates with reduced mortality.
  • Understanding the impact of antihypertensive medications on cardiac hypertrophy is crucial for patient outcomes.

Purpose of the Study:

  • To conduct a meta-analysis of existing literature.
  • To evaluate the effects of various antihypertensive drugs on cardiac hypertrophy.
  • To compare the efficacy of different drug classes in regressing LVH.

Main Methods:

  • Systematic literature search of Medline (PubMed), Lilacs, and Scielo databases.
  • Keywords used: cardiac hypertrophy, antihypertensive, and mortality.
  • Analysis focused on studies investigating antihypertensive drug effects on ventricular hypertrophy.

Main Results:

  • Enalapril (ACE inhibitor) and verapamil (calcium channel blocker) demonstrated LVH regression in animal models.
  • Nifedipine (calcium channel blocker) showed comparable effects to enalapril.
  • Indapamide (diuretic) exhibited a stronger effect than enalapril; losartan (AT1 receptor antagonist) outperformed atenolol (beta-blocker) in LVH regression.

Conclusions:

  • Antihypertensive medications induce varying degrees of hypertrophic regression.
  • Specific drug classes, such as ACE inhibitors, calcium channel blockers, diuretics, and ARBs, show potential in managing LVH.
  • Further research may elucidate optimal drug selection for LVH regression and mortality reduction.
Abstract

Keywords:
CardiologyCardiomyopathyHypertrophicHypertrophyLeft ventricle hypertension

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