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Designing Porous Silicon Films as Carriers of Nerve Growth Factor
Published on: January 25, 2019
Topical administration of adrenergic receptor pharmaceutics and nerve growth factor
1Departments of Ophthalmology and Anatomy and Neurobiology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN 38163, USA. jsteinl1@uthsc.edu
Abstract:
Topical application of nerve growth factor (NGF) and adrenergic receptor pharmaceutics are currently in use for corneal ulcers and glaucoma. A recent interest in the neuroprotective abilities of NGF has led to a renewed interest in NGF as a therapeutic for retinal and choroidal diseases. NGF can promote cell proliferation through actions of the TrkA receptor or promote apoptosis through receptor p75(NTR). This understanding has led to novel interest in the role of NGF for diseases of the posterior eye. The role of beta-adrenergic receptor agonists and antagonists for treatments of glaucoma, diabetic retinopathy, and their potential mechanisms of action, are still under investigation. This review discusses the current knowledge and applications of topical NGF and adrenergic receptor drugs for ocular disease.
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