Related Experiment Video
Updated: Jun 10, 2026
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Antiproliferative diterpenoids from the leaves of Isodon rubescens
Xue-Mei Gao1, Xiao Luo, Jian-Xin Pu
1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, People's Republic of China.
Abstract:
A phytochemical study of Isodon rubescens leaves led to the isolation of five new diterpenoids, isorubesins A-E ( 1- 5), and fifteen known diterpenoids. The structures of these new compounds were elucidated by spectroscopic evidence. Most of the diterpenoids were tested for cytotoxicity against NB4, A549, SHSY5Y, PC3, and MCF7 human tumor cells. Some of them showed potent inhibitory activity. Compound 5 is the first reported atisane-type diterpenoid from this plant.