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Published on: July 27, 2014
Fetal allogeneic umbilical cord cell transplantation improves motor function in spinal cord-injured rats
Bulent Erdogan1, Murad Bavbek, Iffet Feride Sahin
1Fatih University, Faculty of Medicine, Department of Neurosurgery, and Ministry of Health, Diskapi Educational and Research Hospital, Ankara, Turkey. uberdogan@yahoo.com
Aim:
The objective of this study was to investigate whether the transplantation of fetal umbilical cord tissue cells as a source of stem cells into the acutely injured spinal cord would produce some regenerations and/or functional recovery in a rat model of spinal cord injury.
Material And Methods:
Five pregnant albino Wistar rats of 12 days gestation were used for obtaining an umbilical cord cell graft. At the second stage of the experiment only Th8-Th9 laminectomy was performed in Group A animals while Group B animals underwent spinal cord hemitransection. The cultured fetal umbilical cord cells coated with Alginate Gel were placed into the lesion cavity immediately after surgery in Group C animals. Group D animals received only Alginate gel sponges into the injured area. All experiment groups were analyzed histologically and immunohistochemically (GFAP, Ki-67, and Pan cadherin) and for motor function after surgery.
Results:
The umbilical cord cell transplanted animals showed a significant motor recovery compared to non-transplanted animals at 8 and 21 days after spinal cord injury (p=0.008). Significant GFAP and Ki-67 expressions were noted in transplanted animals (p=0.048) suggesting astroglial proliferation.
Conclusion:
Our findings support the possibility of some functional recovery after umbilical cord cell transplantation following spinal cord injury.
