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Updated: Jun 10, 2026

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
Published on: October 4, 2021
Juvenile levodopa-responsive Parkinsonism with early orobuccolingual dyskinesias and cognitive impairment
Alberto J Espay1, Dominic C Paviour, John D O'Sullivan
1Department of Neurology, UC Neuroscience Institute, University of Cincinnati, Cincinnati, Ohio, USA. espayaj@ucmail.uc.edu
Abstract:
A 13-year old girl presented with slowly progressive rest tremor of the hands, bradykinesia, and rigidity. The symptoms improved with dopaminergic medications, but severe drug-induced dyskinesias developed early. She subsequently developed cognitive slowing and difficulty initiating saccadic eye movements. She went on to have deep brain stimulation surgery. Experts discuss the syndromal diagnosis and predict the underlying pathology. The pathological diagnosis is given and clinical learning points are considered.
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