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Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
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Published on: October 10, 2025

Current trends in Irish perinatal mortality.

R Mahony1, M E Foley, C O'Herlihy

  • 1National Maternity Hospital, Holies St., Dublin 2.

Irish Medical Journal
|July 31, 2010
PubMed
Summary
This summary is machine-generated.

Despite increased obstetric interventions, perinatal mortality significantly decreased between 1984-2007 due to fewer deaths from prematurity, placental abruption, and intrauterine growth retardation. However, unexplained stillbirth rates remained unchanged.

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Published on: January 12, 2018

Area of Science:

  • Perinatal Medicine
  • Obstetrics
  • Neonatalogy

Background:

  • Perinatal mortality remains a significant concern in obstetrics.
  • Understanding trends and causes of perinatal death is crucial for improving outcomes.
  • The National Maternity Hospital has collected extensive data on births and perinatal deaths over several decades.

Purpose of the Study:

  • To analyze trends in perinatal mortality over a 24-year period.
  • To identify changes in the causes of perinatal deaths, including stillbirths and neonatal deaths.
  • To investigate the relationship between obstetric interventions and perinatal mortality rates.

Main Methods:

  • Retrospective review of 176,620 births from 1984-2007.
  • Categorization of stillbirths by presumed cause: unexplained, intrauterine growth retardation (IUGR), placental abruption, red cell alloimmunisation (RCA), and prematurity.
  • Analysis of peripartum deaths (intrapartum and first week neonatal).
  • Statistical analysis using Mantel-Haenszel chi-square test for trends.

Main Results:

  • A significant reduction in perinatal mortality was observed during the study period (P < 0.01).
  • Decreases were noted in deaths related to prematurity, term peripartum death, placental abruption, IUGR, and RCA.
  • The unexplained stillbirth rate remained unchanged (p = 0.8) despite a significant increase in obstetric interventions like induction of labor and caesarean section (P < 0.001).

Conclusions:

  • Significant advancements in perinatal care have led to a reduction in preventable perinatal deaths.
  • The persistent rate of unexplained stillbirths highlights the need for further research into underlying mechanisms.
  • Increased obstetric interventions have not significantly impacted the rate of unexplained stillbirths, suggesting a need for targeted strategies.