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Updated: Jun 10, 2026

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1
Published on: February 28, 2025
Synthesis of multivalent tuberculosis and Leishmania-associated capping carbohydrates reveals structure-dependent
Eun-Ho Song1, Alex O Osanya, Christine A Petersen
1Department of Chemistry and The Plant Science Institute, Gilman Hall, Iowa State University, Ames, Iowa 50011-3111, USA.
Abstract:
Mycobacterium tuberculosis and the protozoan parasites of the genus Leishmania are intracellular pathogens that can survive in macrophages--the very white blood cells of the immune system responsible for engulfing and ultimately clearing foreign invaders. The ability of these pathogens to hide within immune cells has made the design of effective therapies, including vaccines, to control tuberculosis and leishmaniasis particularly challenging. Herein we present the synthesis and development of carbohydrate-based probes to demonstrate that changes in pathogen-associated surface oligosaccharides are sufficient to alter cellular immune responses and thereby let a pathogen hide from immune surveillance.
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