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Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

Published on: October 13, 2021

Multicompartment core/shell microgels.

Xiaobo Hu¹, Zhen Tong, L Andrew Lyon

¹School of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.

Journal of the American Chemical Society

|July 31, 2010

Summary

This summary is machine-generated.

Researchers developed novel core/shell microgels with independent responsive components. This design avoids interference, enabling advanced multifunctional delivery systems.

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Published on: October 13, 2021

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Controlled Synthesis and Fluorescence Tracking of Highly Uniform Poly(N-isopropylacrylamide) Microgels

Controlled Synthesis and Fluorescence Tracking of Highly Uniform Poly(N-isopropylacrylamide) Microgels

Published on: September 8, 2016

Area of Science:

Polymer Chemistry
Materials Science
Nanotechnology

Background:

Developing stimuli-responsive microgels is crucial for advanced materials.
Existing microgels often face challenges with component interference.
Designing independent responsive elements within a single particle is a key goal.

Purpose of the Study:

To synthesize multiresponsive poly(N-isopropylacrylamide-co-acrylic acid) (pNIPAm-AAc) microgels with decoupled cores.
To create a "core/double-shell" structure using templated synthesis.
To demonstrate a method for achieving independent responsiveness in microgel systems.

Main Methods:

Utilized poly(N-isopropylmethacrylamide) (pNIPMAm) microgels as templates.
Synthesized a DHEA-cross-linked pNIPMAm inner shell around the core.
Added a pNIPAm-AAc outer shell to form the core/double-shell structure.
Employed periodate-mediated cleavage to erode the inner shell, yielding independent cores.

Main Results:

Successfully prepared multiresponsive core/shell microgels with mechanically and thermodynamically decoupled cores.
Demonstrated the ability to create independent responsive components within a single microgel particle.
Observed significant structural changes and unique multiresponsivity due to the decoupled core structure.

Conclusions:

The developed method enables the creation of microgels with independent functional components.
This approach overcomes antagonistic interferences seen in single-component systems.
These microgels show potential as multifunctional delivery vehicles for various applications.