Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Multipotency and Niche of Bulge Stem Cell

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Folliculogenesis

Folliculogenesis

Folliculogenesis is the development of ovarian follicles, the specialized structures within the ovarian cortex where oogenesis, or egg development, occurs. This process is essential for female reproductive health and begins during fetal development when primordial follicles are formed. Each primordial follicle comprises a primary oocyte in the center, surrounded by a single layer of squamous pre-granulosa cells. These follicles remain dormant in late prophase I of meiosis until triggered by...

Accessory Structures of the Skin: Hair Growth and Types

Accessory Structures of the Skin: Hair Growth and Types

Hair growth begins with the production of keratinocytes by the basal cells of the hair bulb. As new cells are deposited at the hair bulb, the hair shaft is pushed through the follicle toward the surface. Keratinization is completed as the cells are pushed to the skin surface to form the shaft of hair that is externally visible. The external hair is completely dead and composed entirely of keratin. Hair can be cut or shaven without damaging the hair structure because the cut is superficial. Most...

Papillary Dermis

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...

Accessory Structures of the Skin: Hair and Hair Follicles

Accessory Structures of the Skin: Hair and Hair Follicles

Hair and hair follicles are integral components of the integumentary system. Hair is a filamentous structure composed mainly of a protein called keratin. It is found on the surface of the skin throughout the body, except for areas such as the palms of the hands and soles of the feet.
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Establishing a Hospital Artificial Intelligence Committee to Improve Patient Care.

Federal practitioner : for the health care professionals of the VA, DoD, and PHS·2022

Same author

Artificial Intelligence: Review of Current and Future Applications in Medicine.

Federal practitioner : for the health care professionals of the VA, DoD, and PHS·2022

Same author

Using Artificial Intelligence for COVID-19 Chest X-ray Diagnosis.

Federal practitioner : for the health care professionals of the VA, DoD, and PHS·2020

Same author

Comparing Artificial Intelligence Platforms for Histopathologic Cancer Diagnosis.

Federal practitioner : for the health care professionals of the VA, DoD, and PHS·2019

Same author

Warfarin pharmacogenomics: recommendations with available patented clinical technologies.

Recent patents on biotechnology·2014

Same author

Hepatitis C genotype analysis: results in a large veteran population with review of the implications for clinical practice.

Annals of clinical and laboratory science·2012

Search research articles

Related Experiment Video

Updated: Jun 10, 2026

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Published on: April 12, 2024

Basaloid follicular hamartoma.

Omie Mills¹, L Brannon Thomas

¹Department of Pathology and Cell Biology, University of South Florida, Palmetto, FL 34221, USA. omills@health.usf.edu

Archives of Pathology & Laboratory Medicine

|July 31, 2010

Summary

Basaloid follicular hamartoma, a benign skin lesion, can mimic basal cell carcinoma. Research explores its potential premalignant nature and links to patched gene mutations, guiding monitoring and treatment.

Area of Science:

Dermatology
Oncology
Genetics

Background:

Basaloid follicular hamartoma (BFH) is a benign skin neoplasm.
BFH can be clinically and histologically misdiagnosed as basal cell carcinoma (BCC).
BFH shares a genetic pathway (patched gene mutation) with nevoid basal cell carcinoma syndrome.

Purpose of the Study:

To evaluate the premalignant potential of basaloid follicular hamartoma.
To differentiate BFH from basal cell carcinoma.
To review current and experimental treatment strategies for BFH.

Main Methods:

Review of clinical and histological features of BFH.
Analysis of genetic links, including patched gene mutations.
Examination of reported cases of malignant transformation within BFH.

More Related Videos

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Related Experiment Videos

Last Updated: Jun 10, 2026

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Published on: April 12, 2024

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Main Results:

BFH requires careful differentiation from BCC due to potential for malignant transformation.
Patched gene mutations are implicated in BFH development.
Malignant changes within BFH highlight the need for vigilant monitoring.

Conclusions:

BFH may possess premalignant potential, necessitating accurate diagnosis and surveillance.
Understanding the genetic basis of BFH aids in risk assessment.
Appropriate management strategies are crucial for patients with BFH.