Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antibiotic Selection00:57

Antibiotic Selection

Overview
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
Applications of Molecular Taxonomy01:20

Applications of Molecular Taxonomy

Molecular taxonomy has revolutionized the understanding and classification of bacteria, providing precise insights into their diversity, evolutionary relationships, and ecological roles. By utilizing molecular techniques such as DNA sequencing and fingerprinting, researchers have made significant strides in various fields related to bacterial studies.Resolving Taxonomic AmbiguitiesMolecular taxonomy has been instrumental in distinguishing closely related bacterial species initially thought to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dental devices and antimicrobial resistance: challenges, innovations, and regulatory compliances.

Frontiers in medical technology·2026
Same author

Medical device shelf-life and recalls: navigating healthcare challenges.

Expert review of medical devices·2025
Same author

Software as Medical Devices: requirements and regulatory landscape in the United States.

Expert review of medical devices·2025
Same author

US regulatory compliance for medical combination products: an overview.

Frontiers in medical technology·2024
Same author

Navigating regulatory and policy challenges for AI enabled combination devices.

Frontiers in medical technology·2024
Same author

Medical Device Sterilization and Reprocessing in the Era of Multidrug-Resistant (MDR) Bacteria: Issues and Regulatory Concepts.

Frontiers in medical technology·2022
Same journal

Protease-driven approaches for wound eschar debridement and biofilm disruption: current advances, future prospects, and limitations.

Critical reviews in microbiology·2026
Same journal

Environmental regulation of pathogenicity islands by nucleoid-associated proteins in bacteria.

Critical reviews in microbiology·2026
Same journal

New strains, new threats: the rise of atypical non-typhoidal <i>Salmonella</i> serovars and what it means for global health.

Critical reviews in microbiology·2026
Same journal

Tripartite warfare: decoding the cell-virus-virophage arms race.

Critical reviews in microbiology·2026
Same journal

Anti-<i>Candida albicans</i> natural products: convergent technologies revolutionizing discovery from bioactivity assessment to targeted mechanisms.

Critical reviews in microbiology·2026
Same journal

Retraction Notice.

Critical reviews in microbiology·2026
See all related articles

Related Experiment Video

Updated: Jun 10, 2026

Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing
08:19

Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing

Published on: July 7, 2020

Using genomics to develop novel antibacterial therapeutics.

Nagathihalli S Nagaraj1, Om V Singh

  • 1Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. nagaraj.nagathihalli@vanderbilt.edu

Critical Reviews in Microbiology
|July 31, 2010
PubMed
Summary
This summary is machine-generated.

Genomic data and omics technologies accelerate the discovery of new antimicrobial drug targets. Computational analysis of bacterial genomes aids in identifying novel therapeutic strategies against pathogens.

More Related Videos

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

Related Experiment Videos

Last Updated: Jun 10, 2026

Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing
08:19

Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing

Published on: July 7, 2020

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

Area of Science:

  • Microbiology
  • Genomics
  • Drug Discovery

Background:

  • The genomics era provides complete microbial genome sequences, enabling computational analysis of bacterial genomes and DNA structure/function.
  • Pathogen genomes offer crucial information for identifying new antimicrobial agent targets.
  • High-throughput omics technologies and multiple isolate availability have accelerated the discovery of novel therapeutic targets.

Purpose of the Study:

  • To discuss key aspects of bacterial genomes.
  • To advocate for omics-based techniques in discovering new therapeutic targets.
  • To focus on extracellular bacterial pathogens.

Main Methods:

  • Computational analysis of microbial genome sequences.
  • Application of high-throughput omics technologies.
  • Comparative genomics of multiple isolates within species.

Main Results:

  • Genomic data facilitates understanding of bacterial DNA structure and function.
  • Identification of potential targets for novel antimicrobial agents.
  • Accelerated discovery of therapeutic targets through omics approaches.

Conclusions:

  • Genomics and omics technologies are pivotal for advancing antimicrobial drug discovery.
  • Computational approaches are essential for analyzing bacterial genomes.
  • Targeting extracellular bacterial pathogens can be significantly enhanced by omics-based strategies.