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Related Experiment Video

Updated: Jun 10, 2026

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

Published on: December 16, 2022

Bone marrow-derived cells and hypertension.

Ki E Park¹, Carl J Pepine

¹Division of Cardiovascular Medicine, University of Florida College of Medicine, 1600 SW Archer Rd, PO Box 100277, Gainesville, FL 32610-0277, USA.

Expert Review of Cardiovascular Therapy

|July 31, 2010

Summary

This summary is machine-generated.

Hypertension impairs vascular progenitor cell function, increasing risks for cardiovascular disease. This review focuses on bone marrow-derived progenitor cells and their critical role in hypertension-related vascular dysfunction.

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Last Updated: Jun 10, 2026

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

Published on: December 16, 2022

Visualizing Leukocyte Rolling and Adhesion in Angiotensin II-Infused Mice: Techniques and Pitfalls

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Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

Area of Science:

Cardiovascular Science
Vascular Biology
Hypertension Research

Background:

Inadequate organ perfusion is a primary driver of hypertension-related adverse outcomes.
Vascular health improvement strategies focus on reducing vessel wall injury and enhancing repair mechanisms.
Vascular progenitor cells and angiogenesis are key to cardiovascular repair.

Purpose of the Study:

To review recent findings on vascular progenitor cell function in hypertension.
To highlight the link between impaired progenitor cell function and increased cardiovascular disease risk.
To focus on bone marrow-derived progenitor cells as a critical defense mechanism in hypertension.

Main Methods:

Literature review of recent findings on vascular progenitor cells in hypertension.
Analysis of the role of bone marrow-derived progenitor cells in vascular repair.
Synthesis of evidence linking progenitor cell dysfunction to hypertension-related risks.

Main Results:

Limitations in vascular progenitor cell function are evident in hypertension.
Impaired progenitor cell function contributes to increased risks for coronary artery disease.
Bone marrow-derived progenitor cells play a pivotal role in the body's defense against vascular damage in hypertension.

Conclusions:

Dysfunctional vascular progenitor cells in hypertension underlie significant adverse vascular outcomes.
Understanding these cellular mechanisms offers potential for future therapeutic strategies.
Bone marrow-derived progenitor cells are central to vascular health maintenance in the context of hypertension.