Related Experiment Video

Updated: Jun 10, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
12:09

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

TRPM2 channel properties, functions and therapeutic potentials

Lin-Hua Jiang1, Wei Yang, Jie Zou

  • 1University of Leeds, Institute of Membrane and Systems Biology, England, UK. l.h.jiang@leeds.ac.uk

Expert Opinion on Therapeutic Targets
|July 31, 2010
PubMed
Abstract

Insights

Transient receptor potential melastatin 2 (TRPM2) channels are activated by oxidative stress and influence calcium homeostasis. Targeting TRPM2 offers a potential therapeutic strategy for diseases linked to oxidative stress.

Area of Science:

  • Cellular biology
  • Physiology
  • Pathophysiology

Background:

  • Oxidative stress disrupts intracellular calcium homeostasis, contributing to inflammatory, cardiovascular, and neurodegenerative diseases.
  • Reactive oxygen species are key mediators of this disruption.

Purpose of the Study:

  • To review the current understanding of Transient Receptor Potential Melastatin 2 (TRPM2) channel properties.
  • To explore the role of TRPM2 in oxidant stress signaling and cellular functions.

Main Methods:

  • Review of existing research on TRPM2 channel expression and function.
  • Analysis of TRPM2-mediated calcium influx in various physiological and pathophysiological contexts.

Main Results:

  • TRPM2 acts as a cellular redox sensor, forming a Ca(2+)-permeable channel activated by oxidative stress.
  • TRPM2 channel-mediated calcium influx is implicated in insulin release, cytokine production, endothelial permeability, and microglia activation.

Conclusions:

  • TRPM2 channels play a significant role in oxidant stress signaling.
  • TRPM2 represents a potential novel therapeutic target for oxidative stress-related diseases.

More Related Videos

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice08:35

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

Related Concept Videos

Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
Non-gated Ion Channels01:24

Non-gated Ion Channels

Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism.
Ligand-gated Ion Channels01:19

Ligand-gated Ion Channels

Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that include the...