Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Herniated Intervertebral Disc l: Introduction

Herniated Intervertebral Disc l: Introduction

Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...

Drug Delivery: Parenteral Route

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...

Secondary Spinal Cord Injury llI: Pathophysiology

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Comparison of Retinal Nerve Fiber Layer Thickness in Glaucomatous and Nonglaucomatous Patients in Tertiary Care Hospital.

Annals of African medicine·2026

Same author

On-chip gain elements for integrated photonics.

Optics express·2025

Same author

'Tortoise shell appearance' of parotid gland in advanced Sjogren's syndrome.

QJM : monthly journal of the Association of Physicians·2024

Same author

Molecular detection of <i>Salmonella</i> isolated from commercial chicken.

Iranian journal of veterinary research·2022

Same author

Bronco T (Shirisadi kasaya), a polyherbal formulation prevents LPS induced septicemia in rats.

European review for medical and pharmacological sciences·2022

Same author

Effect of a dietary supplement on the reduction of lymphedema-progression in mouse tail-cut model.

European review for medical and pharmacological sciences·2021

Search research articles

Related Experiment Video

Updated: Jun 10, 2026

Efficacy of Fu's Subcutaneous Needling on Sciatic Nerve Pain: Behavioral and Electrophysiological Changes in a Chronic Constriction Injury Rat Model

Efficacy of Fu's Subcutaneous Needling on Sciatic Nerve Pain: Behavioral and Electrophysiological Changes in a Chronic Constriction Injury Rat Model

Published on: June 30, 2023

Sciatic nerve injury from intramuscular injection: a persistent and global problem.

P Mishra¹, M D Stringer¹

¹Wellington School of Medicine and Health Sciences, University of Otago, Wellington, New ZealandOtago School of Medical Sciences, University of Otago, Dunedin, New Zealand.

International Journal of Clinical Practice

|July 31, 2010

Summary

This summary is machine-generated.

Intramuscular injections in the buttock can cause sciatic nerve injury, a persistent global issue. Promoting safer injection sites and practices is crucial for preventing these avoidable, devastating complications.

More Related Videos

An In Vivo Murine Sciatic Nerve Model of Perineural Invasion

An In Vivo Murine Sciatic Nerve Model of Perineural Invasion

Published on: April 23, 2018

Related Experiment Videos

Last Updated: Jun 10, 2026

Efficacy of Fu's Subcutaneous Needling on Sciatic Nerve Pain: Behavioral and Electrophysiological Changes in a Chronic Constriction Injury Rat Model

Efficacy of Fu's Subcutaneous Needling on Sciatic Nerve Pain: Behavioral and Electrophysiological Changes in a Chronic Constriction Injury Rat Model

Published on: June 30, 2023

An In Vivo Murine Sciatic Nerve Model of Perineural Invasion

An In Vivo Murine Sciatic Nerve Model of Perineural Invasion

Published on: April 23, 2018

Area of Science:

Medical Science
Patient Safety
Clinical Practice Guidelines

Background:

Intramuscular (i.m.) injections into the buttock pose a risk of sciatic nerve damage.
Understanding safe injection practices is vital for healthcare professionals.
Previous studies and case reports highlight the potential for i.m. injection-related sciatic nerve injuries.

Purpose of the Study:

To assess the ongoing incidence of sciatic nerve injury from i.m. injections.
To determine the availability and scope of published guidelines for safe i.m. injection techniques.

Main Methods:

Reviewed sciatic nerve injury claims to the New Zealand Accident Compensation Corporation (ACC) from 2005-2008.
Surveyed nursing organizations regarding i.m. injection guidelines.
Conducted a systematic literature review (1989-2009) of i.m. injection-related sciatic nerve injuries.

Main Results:

Eight i.m. injection-related sciatic nerve injury claims were filed with the ACC.
Only one nursing organization had published i.m. injection guidelines, specific to immunizations.
Seventeen reports identified 1506 patients with sciatic nerve injury from i.m. injections, predominantly children.
Nine favorable plaintiff court decisions were found in North America.

Conclusions:

Sciatic nerve injury from buttock i.m. injections is an avoidable yet persistent global problem.
These injuries can have devastating consequences for patients across healthcare systems.
Safer alternative i.m. injection sites should be more widely promoted by medical and nursing bodies.