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Determining the Plane of Cell Division

Determining the Plane of Cell Division

Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function.
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...

Determining the Plane of Cell Division

Determining the Plane of Cell Division

Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function.
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...

Molecular Factors Affecting Cell Division

Molecular Factors Affecting Cell Division

Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...

Long Division of Polynomials

Long Division of Polynomials

Polynomial division is an essential algebraic process to simplify expressions and solve equations. Just as numerical division separates a number into quotient and remainder, polynomial long division partitions a polynomial into simpler components; in this context, the dividend is the polynomial being divided, the divisor is the expression dividing it, and the result is expressed in terms of a quotient and a remainder.The division begins by arranging the dividend and divisor in standard...

Current Dividers

Current Dividers

In parallel electrical connections, resistors are linked between the same pair of nodes, creating an equal voltage across each resistor. Kirchhoff's current law is applied to these connections, establishing that the sum of currents through these resistors equals the source current. Utilizing Ohm's law, the source current is determined as the product of the source voltage and the sum of the reciprocals of individual resistances. This relationship simplifies the process of finding the current...

The Cell Cycle Control System

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...

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Related Experiment Video

Updated: Jun 10, 2026

Mammalian Cell Division in 3D Matrices via Quantitative Confocal Reflection Microscopy

Mammalian Cell Division in 3D Matrices via Quantitative Confocal Reflection Microscopy

Published on: November 29, 2017

Controlling the direction of division.

Stem Cell Research & Therapy

|July 31, 2010

Summary

Gut stem cells exhibit biased spindle orientation and DNA retention, crucial for tissue maintenance. Mutations in the Apc protein disrupt these features, impacting stem cell function.

Area of Science:

Stem cell biology
Cellular dynamics
Developmental biology

Background:

Gut stem cells possess biased spindle orientation and asymmetric label-retaining DNA retention.
These stem cell properties are compromised in mouse and human tissues with mutations in the microtubule-binding protein Apc.
In kidney development, Apc functions downstream of primary cilium signaling to regulate spindle orientation during noncanonical Wnt signaling.

Discussion:

The study investigates the role of the Adenomatous Polyposis Coli (Apc) protein in maintaining gut stem cell characteristics.
It highlights the loss of biased spindle orientation and asymmetric DNA retention in Apc-mutated tissues.
The research connects Apc's function to primary cilium signaling and Wnt pathways in developmental contexts.

Key Insights:

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Using Ex Vivo Live Imaging to Investigate Cell Divisions and Movements During Mouse Dental Renewal

Using Ex Vivo Live Imaging to Investigate Cell Divisions and Movements During Mouse Dental Renewal

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Observing Mitotic Division and Dynamics in a Live Zebrafish Embryo

Observing Mitotic Division and Dynamics in a Live Zebrafish Embryo

Published on: July 15, 2016

Related Experiment Videos

Last Updated: Jun 10, 2026

Mammalian Cell Division in 3D Matrices via Quantitative Confocal Reflection Microscopy

Mammalian Cell Division in 3D Matrices via Quantitative Confocal Reflection Microscopy

Published on: November 29, 2017

Using Ex Vivo Live Imaging to Investigate Cell Divisions and Movements During Mouse Dental Renewal

Using Ex Vivo Live Imaging to Investigate Cell Divisions and Movements During Mouse Dental Renewal

Published on: October 27, 2023

Observing Mitotic Division and Dynamics in a Live Zebrafish Embryo

Observing Mitotic Division and Dynamics in a Live Zebrafish Embryo

Published on: July 15, 2016

Apc is essential for maintaining gut stem cell-specific features like spindle orientation and DNA retention.
Apc's role in stem cell regulation is linked to established developmental signaling pathways.
The findings raise questions about the presence and function of primary cilia in gut stem cells.

Outlook:

Further research is needed to determine if gut stem cells possess primary cilia.
Investigating the potential role of primary cilia in gut stem cell regulation could reveal new therapeutic targets.
Understanding Apc's precise mechanisms in gut stem cells may inform treatments for gastrointestinal diseases.