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Chemical neurostimulation using pulse code modulation (PCM) microfluidic chips.

Farouk Azizi¹, Hui Lu, Hillel J Chiel

¹Department of Electrical and Computer Engineering, Purdue University Calumet, Hammond, IN 46323, USA. fazizi@calumet.purdue.edu

Journal of Neuroscience Methods

|July 31, 2010

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Researchers developed a microfluidic device for chemical neurostimulation. This technology precisely controls chemical concentrations to induce neural activity, paving the way for new implantable devices.

Area of Science:

Neuroscience
Biotechnology
Microfluidics

Background:

Microfluidic devices offer precise control for biological studies.
Chemical stimulation is a key method for understanding neural networks.
Aplysia californica provides a model system for studying neural control of behavior.

Purpose of the Study:

To implement a microfluidic device for localized chemical neurostimulation.
To investigate the neural control of ingestive behavior in Aplysia.
To explore the potential for in vivo applications of chemical neurostimulation.

Main Methods:

Fabrication of a polydimethylsiloxane (PDMS) microfluidic chip.
Digital control of carbachol concentration for localized stimulation.

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In vitro study of Aplysia californica ganglia.

Main Results:

The microfluidic chip successfully induced ingestive-like motor patterns.
Rhythmic neural activity was controllably elicited.
The device demonstrated repeatable stimulation of neural bursts.

Conclusions:

Microfluidic chemical neurostimulation is feasible for in vitro studies.
The developed device shows potential for controlling neural activity in vivo.
This technique could lead to new therapeutic strategies for neural disorders.