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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

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Related Experiment Video

Updated: Jun 10, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

Allergic triggers in atopic dermatitis.

Jean-Christoph Caubet1, Philippe A Eigenmann

  • 1University Hospitals of Geneva, Geneva, Switzerland.

Immunology and Allergy Clinics of North America
|July 31, 2010
PubMed
Summary

Identifying and avoiding allergens can significantly improve atopic dermatitis (AD) flares. Diagnostic tests like skin-prick tests and atopy patch tests (APT) help pinpoint triggers, leading to better eczema management.

Area of Science:

  • Immunology
  • Dermatology
  • Allergology

Background:

  • Atopic dermatitis (AD) is a chronic inflammatory skin condition.
  • Allergens, including food and environmental types, can trigger eczema flares in susceptible individuals.
  • Identifying specific allergens is crucial for managing AD in a subset of patients.

Purpose of the Study:

  • To review the diagnostic approaches for identifying allergic triggers in atopic dermatitis.
  • To discuss the benefits of allergen avoidance strategies for managing AD.
  • To determine when diagnostic and avoidance measures are most beneficial.

Main Methods:

  • Review of diagnostic methods including skin-prick tests (SPT), serum-specific IgE tests, atopy patch tests (APT), and oral food challenges (OFC).

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  • Analysis of the efficacy of allergen elimination therapies.
  • Correlation of diagnostic findings with clinical improvement in AD patients.

    • Main Results:

    • Diagnostic tests like SPT, serum-specific IgE, and APT, guided by patient history, can identify allergic triggers.
    • Atopy patch tests (APT) are valuable diagnostic tools for allergic triggers in AD.
    • Elimination of identified allergens, particularly food allergens, can lead to significant improvement in AD symptoms.
    • Inhalant allergens can also contribute to AD flares and may benefit from avoidance.

    Conclusions:

    • Allergen identification and subsequent avoidance are effective therapeutic strategies for a subset of atopic dermatitis patients.
    • A combination of diagnostic tests, tailored to individual patient history, aids in pinpointing relevant allergens.
    • Management of AD can be significantly enhanced by addressing specific food and environmental triggers.