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Updated: Jun 10, 2026

Bacterial Expression and Purification of Human Matrix Metalloproteinase-3 using Affinity Chromatography
Published on: March 30, 2022
Hunting-ton for new proteases: MMPs as the new target?
1Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA. johri.ashu@gmail.com
Abstract:
Mutant huntingtin proteolysis mediated by various proteases plays a key role in Huntington's disease (HD) pathogenesis. In this issue of Neuron, Miller et al. have identified 11 proteases, including matrix metalloproteinases (MMPs), that when inhibited reduce huntingtin proteolysis and produce beneficial therapeutic effects. These findings provide new insights into huntingtin proteolysis and its potential as a therapeutic target.
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