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Updated: Jun 10, 2026

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation

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Published on: January 14, 2014

Extensive intracranial juvenile xanthogranulomas.

P Lalitha¹, M Ch B Reddy, K J Reddy

¹Department of Radiology, Focus Diagnostics, Hyderabad, India. lalithamanohar@rediffmail.com

AJNR. American Journal of Neuroradiology

|July 31, 2010

Summary

Juvenile xanthogranuloma (JXG) is a rare histiocytosis typically presenting with skin lesions in children. This case highlights extensive, multifocal intracranial JXG, an unusual presentation.

Area of Science:

Pediatric Neurology
Dermatology
Histiocytosis Research

Background:

Juvenile xanthogranuloma (JXG) is a rare, non-Langerhans cell histiocytosis.
Typically presents in infants and children with cutaneous or ocular lesions.
Intracranial involvement is rare and often solitary.

Observation:

A pediatric case with extensive central nervous system (CNS) involvement by JXG.
Multiple, solid, enhancing lesions identified on magnetic resonance (MR) imaging.
Lesions were observed in the cerebellum, brain stem, thalami, and cerebral hemispheres.

Findings:

Demonstrates multifocal intracranial JXG, challenging the typical solitary presentation.
Highlights the potential for widespread CNS disease in JXG.

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MR imaging characteristics of extensive intracranial JXG.

Implications:

Broadens understanding of JXG's neurological manifestations.
Suggests comprehensive neuroimaging may be warranted in atypical JXG cases.
Informs differential diagnosis for pediatric intracranial tumors and lesions.