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Related Experiment Video

Updated: Jun 10, 2026

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats
09:12

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats

Published on: March 17, 2019

Dopaminergic network differences in human impulsivity.

Joshua W Buckholtz1, Michael T Treadway, Ronald L Cowan

  • 1Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA. joshua.buckholtz@vanderbilt.edu

Science (New York, N.Y.)
|July 31, 2010
PubMed
Summary
This summary is machine-generated.

Higher impulsivity in humans is linked to lower dopamine D2/D3 autoreceptor binding in the midbrain. This reduction predicts greater dopamine release in the striatum after amphetamine, correlating with craving.

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Last Updated: Jun 10, 2026

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09:54

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Published on: August 10, 2012

Area of Science:

  • Neuroscience
  • Psychopharmacology
  • Neuroimaging

Background:

  • Dopamine (DA) is implicated in impulsivity, but mechanisms linking signaling variability to impulsive traits are unclear.
  • Understanding these links is crucial for addressing impulsivity-related behaviors.

Purpose of the Study:

  • To investigate the relationship between dopamine D2/D3 receptor availability, amphetamine-induced dopamine release, and trait impulsivity in humans.
  • To elucidate the neural mechanisms underlying individual differences in impulsivity.

Main Methods:

  • Utilized dual-scan positron emission tomography (PET) in healthy volunteers.
  • Administered amphetamine and the D2/D3 ligand [18F]fallypride to measure dopamine release and receptor binding.
  • Employed path analysis to model the relationships between variables.

Main Results:

  • Diminished midbrain D2/D3 autoreceptor binding predicted higher trait impulsivity.
  • Greater amphetamine-induced striatal DA release was associated with higher impulsivity and stimulant craving.
  • Decreased midbrain D2/D3 autoreceptor availability partially mediated the effect on trait impulsivity via stimulated striatal DA release.

Conclusions:

  • Midbrain dopamine D2/D3 autoreceptor availability plays a significant role in modulating trait impulsivity.
  • Striatal dopamine release dynamics are a key mechanism linking autoreceptor function to impulsive behavior.
  • Findings provide insights into the neurobiological underpinnings of impulsivity and potential targets for intervention.