Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Genetic Variation

Genetic Variation

Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles, which...

What is Variation?

What is Variation?

Apart from the measures of central tendency, distribution, outliers, and the changing characteristics of data with time, an important characteristic of any data set is its variation or spread. In some data sets, the data values are concentrated closely near the mean; in others, the data values are more widely spread out from the mean.
The range, standard deviation, standard error, and variance are the different measures of variation.
Range: The range is the difference between its maximum and...

Variation

Variation

An important characteristic of any set of data is the variation in the data. In some data sets, the data values are concentrated closely near the mean; in other data sets, the data values are more widely spread out from the mean. The most common measure of variation, or spread, is the standard deviation, which is the square root of variance.
When independent and dependent variables are plotted on a scatter plot, the slope of a line is a value that describes the rate of change between the two...

Variability: Analysis

Variability: Analysis

Measures of variability are statistical metrics that reveal the dispersion pattern within a dataset. They are pivotal in biostatistics, providing insights into the heterogeneity within health and biological data. Variability signifies the degree to which data points diverge from one another, helping researchers understand the potential range of values and associated uncertainty within the data.
The range is a simple measure of variability, indicating the difference between the highest and...

Principles of Pharmacogenetics: Types of Genetic Variants

Principles of Pharmacogenetics: Types of Genetic Variants

The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...

Hepatic Portal System

Hepatic Portal System

The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is responsible...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Reduced ULK1 links impaired autophagy and mitophagy to Alzheimer's disease pathology.

Nature aging·2026

Same author

Comparison of missing data handling methods for variant pathogenicity predictors.

NAR genomics and bioinformatics·2025

Same author

Correction: Lewy body dementia: exploring biomarkers and pathogenic interactions of amyloid β, tau, and α-synuclein.

Molecular neurodegeneration·2025

Same author

Lewy body dementia: exploring biomarkers and pathogenic interactions of amyloid β, tau, and α-synuclein.

Molecular neurodegeneration·2025

Same author

SMUG1 DNA glycosylase modulates reward behaviour through regulation of olfactory receptor gene expression.

Nucleic acids research·2025

Same author

The C. elegans gba-3 gene encodes a glucocerebrosidase that exacerbates α-synuclein-mediated impairments in deletion mutants.

Translational neurodegeneration·2025

Search research articles

Related Experiment Video

Updated: Jun 10, 2026

Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine

Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine

Published on: December 22, 2017

Varietas: a functional variation database portal.

Jussi Paananen¹, Robert Ciszek, Garry Wong

¹Laboratory of Functional Genomics and Bioinformatics, Department of Neurobiology, A.I. Virtanen Institute for Molecular Sciences and Biocenter Finland, University of Eastern Finland, P.O. Box 1627, FIN-70211 Kuopio, Finland. jussi.paananen@uef.fi

Database : the Journal of Biological Databases and Curation

|July 31, 2010

Summary

This summary is machine-generated.

Varietas is a web database that helps researchers identify functional genomic variations from large datasets. It aids in genome-wide association studies by annotating variations and linking to external databases.

More Related Videos

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

The Terroir Concept Interpreted through Grape Berry Metabolomics and Transcriptomics

The Terroir Concept Interpreted through Grape Berry Metabolomics and Transcriptomics

Published on: October 5, 2016

Related Experiment Videos

Last Updated: Jun 10, 2026

Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine

Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine

Published on: December 22, 2017

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

The Terroir Concept Interpreted through Grape Berry Metabolomics and Transcriptomics

The Terroir Concept Interpreted through Grape Berry Metabolomics and Transcriptomics

Published on: October 5, 2016

Area of Science:

Genomics
Bioinformatics
Population Genetics

Background:

High-throughput sequencing generates millions of genomic variations.
Identifying functional variations in large population studies is challenging.
Genome-wide association studies (GWAS) require efficient data analysis tools.

Purpose of the Study:

To develop a web-based database portal, Varietas, for efficient analysis of genomic variations.
To assist researchers in identifying promising genetic associations from large datasets.
To facilitate the annotation of numerous variations and link them to genes, phenotypes, and diseases.

Main Methods:

Development of a web-based database portal (Varietas).
Integration of data from major SNP and genome databases (Ensembl, dbSNP, GAD, SNPedia).
Batch annotation of genomic variations including SNPs, copy number variants, and indels.
Linking to external genomic databases for comprehensive data exploration.

Main Results:

Varietas provides a centralized platform for retrieving and annotating genomic variation data.
The portal enables batch processing of large variation datasets.
Users can explore relationships between variations, genes, phenotypes, and diseases.
Cross-referencing with external databases facilitates in-depth investigation of genetic associations.

Conclusions:

Varietas serves as a valuable tool for researchers conducting genome-wide association studies.
The database streamlines the process of identifying functional genomic variations.
Varietas enhances the efficiency of exploring and interpreting large-scale genomic data.