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Related Experiment Videos

Development of multiple transitional cell carcinomas in the urinary tract.

T Kakizoe1, K Tobisu, Y Tanaka

  • 1Urology Division, National Cancer Center Hospital, Tokyo.

Japanese Journal of Clinical Oncology
|April 1, 1991
PubMed
Summary

Transitional cell carcinomas in the upper urinary tract frequently lead to bladder cancer. Papillary tumors are often multiple and superficial, while nodular tumors are solitary and invasive. Human papillomavirus (HPV) does not appear to cause multiple bladder tumors.

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Area of Science:

  • Uro-oncology
  • Pathology
  • Cancer Etiology

Background:

  • Transitional cell carcinomas (TCC) can occur in the renal pelvis, ureter, and bladder.
  • Understanding the patterns of TCC multiplicity and associated factors is crucial for diagnosis and treatment.
  • The role of human papillomavirus (HPV) in TCC development, particularly multifocal disease, requires investigation.

Purpose of the Study:

  • To analyze the multiplicity of TCC in the upper urinary tract and bladder.
  • To correlate tumor configuration (papillary vs. nodular) with multiplicity and invasiveness.
  • To investigate the association between TCC multiplicity and mucosal changes like carcinoma in situ (CIS) and dysplasia.
  • To determine the potential involvement of HPV in the development of multiple papillary bladder cancers.

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Main Methods:

  • Retrospective analysis of TCC cases in the renal pelvis, ureter, and bladder.
  • Classification of tumors based on configuration (papillary, nodular) and invasiveness.
  • Assessment of associated mucosal changes (CIS, dysplasia).
  • HPV DNA detection using hybridization techniques in selected tumor and normal bladder tissues.

Main Results:

  • High incidence of subsequent bladder cancer following upper tract TCC (22-67%).
  • Papillary upper tract cancers were more likely to be associated with later bladder cancer development (67%) compared to nodular cancers (13%).
  • In bladder cancer, papillary tumors were frequently multiple (77%) and associated with CIS/dysplasia (57%), whereas nodular tumors were mostly solitary (72%) and associated with CIS/dysplasia (55%).
  • No HPV DNA was detected in papillary bladder cancers or normal bladder mucosa, suggesting HPV is not implicated in multiple bladder tumor development.

Conclusions:

  • Papillary TCCs tend to develop multiply and remain superficial, while nodular TCCs are solitary and invasive.
  • No clear association was found between TCC multiplicity and associated mucosal changes.
  • HPV is unlikely to be a causative factor in the multifocal development of papillary TCC in the bladder.