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Updated: Jun 10, 2026
13:53
The Helsinki Rat Microsurgical Sidewall Aneurysm Model
Published on: October 12, 2014
Small unruptured intracranial aneurysm verification study: SUAVe study, Japan
Makoto Sonobe1, Tomosato Yamazaki, Masahiro Yonekura
1Department of Neurosurgery, National Hospital Organization, Mito Medical Center, Ibaraki, Japan. tysato@hotmail.co.jp
Stroke
|July 31, 2010
Summary
The annual rupture risk for small unruptured aneurysms (<5 mm) is low, around 0.54%. Treatment may be considered for patients under 50 with hypertension and multiple aneurysms measuring >=4 mm.
Area of Science:
- Neurology
- Neurosurgery
- Vascular Medicine
Background:
- The natural history and management of small unruptured aneurysms (<5 mm) are not well-defined.
- Incidental findings of these aneurysms pose a clinical challenge regarding optimal treatment strategies.
Purpose of the Study:
- To prospectively evaluate the natural history of small unruptured aneurysms.
- To determine the optimal management and identify risk factors for rupture and enlargement.
Main Methods:
- A prospective study followed 448 unruptured aneurysms (<5 mm) in 374 patients for a mean of 41.0 months.
- Calculated average annual rupture rates and investigated predictive factors for rupture and enlargement.
Main Results:
- The average annual rupture rate was 0.54% overall, with variations for single (0.34%) and multiple (0.95%) aneurysms.
- Significant predictive factors for rupture included patient age <50, aneurysm diameter >=4.0 mm, hypertension, and aneurysm multiplicity.
Conclusions:
- Small unruptured aneurysms (<5 mm) exhibit a low annual rupture rate.
- Treatment should be carefully considered for patients <50 with hypertension and multiple aneurysms (>=4 mm) to mitigate rupture risk.
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