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Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model
Published on: November 4, 2022
Medical management of metastatic bone disease
Naveen S Vasudev1, Janet E Brown
1Cancer Research UK Clinical Centre at Leeds, University of Leeds, St James's Hospital, Leeds, UK.
Purpose Of Review:
To highlight recent advances in the medical management of metastatic bone disease.
Recent Findings:
Progress has been made in quality of life assessment and pain measurement; in novel ways to use bisphosphonates, especially in the adjuvant setting for prevention of bone metastases and in combination with other pharmaceutical agents, where synergistic enhancement holds high potential; in targeted therapies using novel agents, especially with denosumab which is approaching registration; in the use of bone biomarkers to direct therapy and as surrogate endpoints; in development of radiopharmaceuticals for improved treatment of disseminated bone pain.
Summary:
Metastatic bone disease continues to present management challenges, but these challenges are being met with an increased armamentarium of available interventions.
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