Related Experiment Video

Updated: Aug 9, 2026

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
07:09

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Published on: April 1, 2015

[Blood coagulation system as a component of hereditary predisposition to ischemic heart disease]

Iu P Koshkin, E Sh Khalfen, V A Koshechkin

    Kardiologiia
    |April 1, 1991
    PubMed

    Insights

    A study of 99 families found that blood relatives of myocardial infarction patients have high rates of coronary heart disease (CHD). Measuring antithrombin III activity is recommended for identifying genetic predisposition to CHD in those with a family history.

    Area of Science:

    • Cardiology
    • Genetics
    • Hematology

    Background:

    • Coronary heart disease (CHD) poses a significant health burden.
    • Family history is a known risk factor for CHD.
    • Understanding genetic predisposition is crucial for early detection and prevention.

    Purpose of the Study:

    • To investigate the relationship between family history and CHD affliction.
    • To identify hemostatic parameters associated with genetic predisposition to CHD.
    • To evaluate the utility of specific markers for CHD risk assessment.

    Main Methods:

    • Survey of 99 families with a history of myocardial infarction.
    • Analysis of coagulative and anticoagulative factors in patients and their blood relatives.
    • Examination of hemostatic parameters in relation to CHD and family history.

    Main Results:

    • High prevalence of CHD among blood relatives of myocardial infarction patients.
    • Profound changes in coagulative and anticoagulative factors indicating hypercoagulation tendency.
    • Evidence for genetic determination of hemostatic parameter activity in CHD predisposition.

    Conclusions:

    • The blood coagulative system is a key component of hereditary predisposition to CHD.
    • Antithrombin III activity is a potential marker for genetic predisposition to CHD.
    • Measuring antithrombin III is advisable for individuals with a family history of CHD.

    More Related Videos

    Hemocompatibility Testing of Blood-Contacting Implants in a Flow Loop Model Mimicking Human Blood Flow09:41

    Hemocompatibility Testing of Blood-Contacting Implants in a Flow Loop Model Mimicking Human Blood Flow

    Published on: March 5, 2020

    In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time09:19

    In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time

    Published on: May 24, 2020

    Related Concept Videos

    Coagulation01:06

    Coagulation

    Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
    Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

    Anticoagulant Drugs: Low-Molecular-Weight Heparins

    Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
    Introduction to Hemostasis01:05

    Introduction to Hemostasis

    Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
    The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...
    Coagulation01:09

    Coagulation

    The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
    During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
    Extrinsic and Intrinsic Pathways of Hemostasis01:20

    Extrinsic and Intrinsic Pathways of Hemostasis

    Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
    The Extrinsic Pathway
    The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
    Disorders of Hemostasis01:24

    Disorders of Hemostasis

    Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
    Thromboembolic Disorders
    Two factors primarily cause thromboembolic conditions.