Related Experiment Video
Updated: Jun 10, 2026
10:23
Screening for Melanoma Modifiers using a Zebrafish Autochthonous Tumor Model
Published on: November 13, 2012
A Rare Malignant Triton Tumor.
Kalpalata Tripathy1, Rabinarayan Mallik, Aparajita Mishra
1Department of Pathology, S.C.B. Medical College, Cuttack, India.
Case Reports in Neurology
|July 31, 2010
Summary
Malignant triton tumor, a rare cancer of nerve cells with muscle differentiation, was diagnosed in a 40-year-old man with a buttock mass. This aggressive tumor, confirmed by S-100 protein staining, has a poor prognosis.
Area of Science:
- Oncology
- Pathology
- Surgical Oncology
Background:
- Malignant peripheral nerve sheath tumors (MPNSTs) are rare and aggressive neoplasms.
- Malignant triton tumors (MTTs) represent a subtype of MPNSTs with rhabdomyoblastic differentiation.
- Neurofibroma is a benign nerve sheath tumor that can rarely transform into MPNSTs.
Observation:
- A case of malignant triton tumor was identified in a 40-year-old male patient.
- The patient presented with a mass located in the buttock region.
- The patient had a prior diagnosis of neurofibroma in the same anatomical area.
Findings:
- Histomorphological examination and S-100 protein immunostaining confirmed the diagnosis of malignant triton tumor.
- The tumor exhibited rhabdomyoblastic differentiation.
- The buttock region is an extremely rare site for malignant triton tumors.
Implications:
- Malignant triton tumors have a generally poor prognosis due to their aggressive nature.
- This case highlights the importance of considering rare tumor types in unusual locations.
- Reporting rare occurrences aids in understanding the epidemiology and clinical behavior of malignant triton tumors.
More Related Videos
Related Concept Videos
01:20The Retinoblastoma Gene
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
02:30Metastasis
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...