Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

The Extracellular Matrix

The Extracellular Matrix

Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...

The Extracellular Matrix

The Extracellular Matrix

In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.Composition of the Extracellular MatrixThe extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse molecules.

Regulation of Angiogenesis and Blood Supply

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

Extracellular Matrix

Extracellular Matrix

Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Re-expression of miR-200s in claudin-low mammary tumor cells alters cell shape and reduces proliferation and invasion potentially through modulating other miRNAs and SUZ12 regulated genes.

Cancer cell international·2021

Same author

Osteopontin regulates proliferation, apoptosis, and migration of murine claudin-low mammary tumor cells.

BMC cancer·2016

Same author

Hepatitis E virus in patients with decompensated chronic liver disease: a prospective UK/French study.

Alimentary pharmacology & therapeutics·2015

Same author

Evaluation of a potassium removal filter on irradiated red cells stored in SAGM.

Transfusion medicine (Oxford, England)·2015

Same author

Costs and quality of life associated with acute upper gastrointestinal bleeding in the UK: cohort analysis of patients in a cluster randomised trial.

BMJ open·2015

Same author

Storage of apheresis platelet concentrates after manual replacement of >95% of plasma with PAS 5.

Vox sanguinis·2014

Search research articles

Related Experiment Video

Updated: Jun 10, 2026

Fibroblast-Derived 3D Matrix System Applicable to Endothelial Tube Formation Assay

Fibroblast-Derived 3D Matrix System Applicable to Endothelial Tube Formation Assay

Published on: December 26, 2019

Extracellular matrix proteins and tumor angiogenesis.

N E Campbell¹, L Kellenberger, J Greenaway

¹Department of Biomedical Sciences, University of Guelph, Guelph, ON, Canada N1G 2W1.

Journal of Oncology

|July 31, 2010

Summary

The extracellular matrix (ECM) and its proteins are crucial regulators of tumor growth. This review explores how ECM components influence angiogenesis, a vital process for tumor expansion.

More Related Videos

A Label-Free Segmentation Approach for Intravital Imaging of Mammary Tumor Microenvironment

A Label-Free Segmentation Approach for Intravital Imaging of Mammary Tumor Microenvironment

Published on: May 24, 2022

Strategic Endothelial Cell Tube Formation Assay: Comparing Extracellular Matrix and Growth Factor Reduced Extracellular Matrix

Strategic Endothelial Cell Tube Formation Assay: Comparing Extracellular Matrix and Growth Factor Reduced Extracellular Matrix

Published on: August 14, 2016

Related Experiment Videos

Last Updated: Jun 10, 2026

Fibroblast-Derived 3D Matrix System Applicable to Endothelial Tube Formation Assay

Fibroblast-Derived 3D Matrix System Applicable to Endothelial Tube Formation Assay

Published on: December 26, 2019

A Label-Free Segmentation Approach for Intravital Imaging of Mammary Tumor Microenvironment

A Label-Free Segmentation Approach for Intravital Imaging of Mammary Tumor Microenvironment

Published on: May 24, 2022

Strategic Endothelial Cell Tube Formation Assay: Comparing Extracellular Matrix and Growth Factor Reduced Extracellular Matrix

Strategic Endothelial Cell Tube Formation Assay: Comparing Extracellular Matrix and Growth Factor Reduced Extracellular Matrix

Published on: August 14, 2016

Area of Science:

Oncology
Cell Biology
Biochemistry

Background:

Tumor development involves complex cellular interactions and communication.
The tumor stroma, rich in extracellular matrix (ECM), plays a significant role in solid tumors.
Matricellular proteins within the ECM regulate proteins involved in tumorigenic processes.

Purpose of the Study:

To discuss the role of the extracellular matrix and ECM proteins in regulating tumor angiogenesis.
To highlight the importance of ECM in controlling tumor growth and progression.

Main Methods:

Literature review of studies on ECM, matricellular proteins, and angiogenesis in tumors.
Analysis of the regulatory mechanisms of ECM components on angiogenic factors.
Synthesis of current understanding of ECM's impact on tumor vascularization.

Main Results:

The ECM provides structural support and sequesters various regulatory molecules.
Proteases within the ECM modulate the bioavailability and activity of angiogenic factors.
ECM proteins directly and indirectly influence the formation of new blood vessels.

Conclusions:

The extracellular matrix is a critical regulator of tumor angiogenesis.
Targeting ECM-mediated pathways presents potential therapeutic strategies for cancer treatment.
Understanding ECM-angiogenesis interplay is vital for advancing cancer research.