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Click-xylosides mitigate glioma cell invasion in vitro
Karthik Raman1, Balagurunathan Kuberan
1Department of Bioengineering, University of Utah, 30 S 2000 E, Skaggs Hall Room 307, Salt Lake City, Utah 84112, USA.
Molecular Biosystems
|July 31, 2010
Abstract:
Tumor related invasion allows cancers to spread beyond tissue boundaries and significantly affects patient prognosis. In this study we show that several click-xylosides markedly inhibit the invasive capability of a highly invasive glioma cell line in vitro. These novel xylosides are promising chemical biology tools to probe the role of the proteoglycan glycome in regulating tumor biology.
