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Do risk factors for persistent asthma modify lung function in infants and young children with recurrent wheeze?
Esteban Keklikian1, Manuel Sanchez-Solis, Angel Jose Bonina
1Paediatric Pulmonology Unit, Paediatric Department, Palmaplanas Clinic, Palma de Mallorca, Spain.
Pediatric Pulmonology
|July 31, 2010
Summary
Infants with recurrent wheezing and a positive asthma predictive index (API) show significantly lower lung function (V'FRC Z-scores) at an early age. This highlights early lung function differences in predicting persistent asthma risk.
Area of Science:
- Pediatric Pulmonology
- Respiratory Medicine
- Asthma Research
Background:
- Limited data exists on how persistent asthma risk in recurrent wheezing (RW) infants affects early lung function.
- The Asthma Predictive Index (API) is used to identify infants at risk for persistent asthma.
Purpose of the Study:
- To compare lung function in RW infants and young children based on a positive or negative API.
- To investigate the relationship between API status and early lung function parameters.
Main Methods:
- Recruited RW infants and young children from two Spanish centers.
- Measured lung function using the thoraco-abdominal compression technique (RCT), focusing on maximal flow at functional residual capacity (V'FRC) Z-scores.
- Collected data on gender, age, length, weight, and parental smoking habits.
Main Results:
- Infants with a positive API (n=50) had significantly lower V'FRC Z-scores compared to those with a negative API (n=41) (-2.01 vs. -1.64, P=0.026).
- No significant effect of study center or parental smoking on lung function was observed.
Conclusions:
- RW infants with a positive API exhibit significantly reduced lung function at an early age.
- Early lung function assessment in RW infants may aid in identifying those at higher risk for persistent asthma.
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