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Related Concept Videos

Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Three Developmental Domains01:29

Three Developmental Domains

Human development is typically examined across three main domains: physical, cognitive, and socio-emotional. These domains represent the significant areas of change and continuity throughout the lifespan, from infancy to late adulthood.
Physical Development
Physical processes, also known as maturation, encompass the biological changes that occur across an individual's life. These changes begin with genetic inheritance and continue through various stages, including growth in height and weight,...
Nursing Clinical Information System01:27

Nursing Clinical Information System

Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
Formulating and Validating Nursing Diagnosis I01:26

Formulating and Validating Nursing Diagnosis I

A nursing diagnosis is written when the nurse recognizes a cluster of essential patient data indicating health problems treated with independent nursing interventions. The standardized terminologies of a nursing diagnosis help nurses identify and treat patients' problems. Every electronic health record that uses nursing diagnosis must employ standard diagnostic terminology. Developing an efficient, individualized care plan begins with accurate nursing diagnoses.
There are thirteen domains for...

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Updated: Jun 10, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

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Published on: September 20, 2018

Locus-specific database domain and data content analysis: evolution and content maturation toward clinical use.

Christina Mitropoulou1, Adam J Webb, Konstantinos Mitropoulos

  • 1Erasmus MC, Faculty of Medicine and Health Sciences, MGC-Department of Cell Biology and Genetics, Rotterdam, The Netherlands.

Human Mutation
|July 31, 2010
PubMed
Summary
This summary is machine-generated.

Locus-specific databases (LSDBs) are crucial for genetic variation data. Analysis of 1,188 LSDBs revealed advancements in data management but highlighted deficiencies in disease descriptions and patient links.

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Area of Science:

  • Genetics
  • Bioinformatics
  • Medical Informatics

Background:

  • Genetic variation databases are essential in healthcare.
  • Locus-specific databases (LSDBs) store disease-causing genetic variants.
  • Some LSDBs function as comprehensive knowledge bases.

Purpose of the Study:

  • To analyze the content and features of 1,188 LSDBs.
  • To identify advancements and deficiencies in LSDBs.
  • To propose improvements for better clinical genetics community service.

Main Methods:

  • Systematic analysis of 1,188 LSDBs.
  • Evaluation of 44 content criteria covering database features and data content.
  • Assessment of data collection, variant summarization, and querying capabilities.

Main Results:

  • Specialized database systems and querying tools have advanced the field and reduced data heterogeneity.
  • Deficiencies include a lack of detailed disease/phenotypic descriptions for variants.
  • Links to patient organizations are often missing.

Conclusions:

  • LSDBs have improved but require enhancements to fully support clinical genetics.
  • Addressing deficiencies would improve LSDB utility for clinicians and researchers.
  • A federated genetic variation browser structure is proposed for better data maintenance and access.