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Updated: Jun 10, 2026
Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
Retinal-image quality and contrast-sensitivity function in age-related macular degeneration
Carolina Ortiz1, José R Jiménez, Francisco Pérez-Ocón
1Departament of Optics, Laboratory of Vision Sciences and Applications, University of Granada, Granada, Spain. ortizh@ugr.es
Purpose:
In this article, retinal-image quality and contrast sensitivity were measured in 25 patients with age-related macular degeneration (ARMD) and 15 patients with normal retinal health.
Materials And Method:
Retinal-image quality was evaluated with an objective device based on the double-pass technique, and for visual performance we measured the contrast-sensitivity function.
Results:
The results from double-pass device revealed the Strehl ratio to be significantly (p < 0.0001) lower for the ARMD group with a 54.3% reduction for 3 mm pupil size and a 46.9% reduction for 4 mm. Contrast-sensitivity function for ARMD subjects was also significantly lower than for the control group (p < 0.05) with a 38.6% reduction.
Conclusions:
Patients affected with ARMD showed poorer retinal-image quality and visual performance than normal subjects. The use of objective devices based on the double-pass technique could be useful for the accurate description of the retinal-image quality of ARMD eyes, in which retinal scattering is significantly increased.
