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Antimycobacterial activity of Indigofera suffruticosa with activation potential of the innate immune system
Camila B de A Carli1, Marcela B Quilles, Daniele C G Maia
1Departamento de Análises Clínicas e Departamento de Ciências Biológicas, UNESP, R. Expedicionariosdo Brasil 1621, 14801-902 Araraquara, SP, Brazil. camilabac@yahoo.com.br
Abstract:
Mycobacterium tuberculosis is responsible for over 8 million cases of tuberculosis (TB) annually. Natural products may play important roles in the chemotherapy of TB. The antimycobacterial activity and the innate immune response of methanol (METH) and dichloromethane (DCM) extracts of Indigofera suffruticosa Miller (Fabaceae) were evaluated. We observed that the minimum inhibitory concentrations (MICs) for METH and DCM extracts were 125 and 1000 microg/mL, respectively. However, they were able to induce the innate immune response through the production of high levels of NO and TNF-alpha (p < 0.001) by peritoneal exudate cells (PECs). These results suggest that I. suffruticosa extracts may have an important immunological role in the control of TB once macrophage activity is induced by them.
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