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Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli

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Thrombolytic therapy for cerebral embolism.

T Hyogo¹, T Kataoka, K Hayase

¹Department of Surgical Neuroangiography, Neurosurgery, Nakamura Memorial Hospital; Sapporo, Japan.

Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences

|August 3, 2010

Summary

Thrombolytic therapy shows promise for cerebral embolism, particularly for middle cerebral artery (MCA) and basilar artery occlusions. Pre-treatment cerebral blood flow (CBF) measurement aids in assessing ischemia severity and preventing complications.

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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

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Published on: August 18, 2015

Area of Science:

Neurology
Vascular Medicine
Interventional Radiology

Background:

Cerebral embolism poses a significant risk for stroke.
Thrombolytic therapy is a potential treatment, but its efficacy varies by occlusion site.
Predicting treatment outcomes and complications is crucial.

Purpose of the Study:

To evaluate the prognosis of thrombolytic therapy for cerebral embolism based on occlusion site.
To assess the role of pre-treatment cerebral blood flow (CBF) measurement in supratentorial cerebral embolism.
To compare thrombolytic therapy outcomes with conservative medical management.

Main Methods:

Analysis of 56 cases of thrombolysis for cerebral embolism.
Comparison of outcomes between thrombolysis and conservative medical therapy groups.
Evaluation of pre-treatment CBF measurements for predicting outcomes and complications.

Main Results:

Thrombolysis was discontinued for internal carotid artery (ICA) embolism due to poor collateral circulation.
Middle cerebral artery (MCA) embolism showed significantly better outcomes with thrombolysis compared to conservative therapy.
Basilar artery embolism demonstrated the highest effectiveness with thrombolysis, despite a high mortality rate.
Pre-treatment CBF measurement proved useful in estimating ischemia severity and avoiding hemorrhagic complications.

Conclusions:

Thrombolytic therapy is a viable option for specific cerebral embolism sites, notably MCA and basilar artery occlusions.
Pre-treatment CBF measurement is critical for optimizing thrombolytic therapy and mitigating risks.
Individualized treatment strategies based on occlusion site and CBF are essential for improving patient prognosis.