Related Experiment Video
Updated: Jun 10, 2026

10:59
Fluorescent End-Labeling and Encapsulation of Long RNAs for Single-Molecule FRET-TIRF Microscopy
Published on: October 18, 2024
Labeling of nucleosides with fluorescent 6-chloro-2,3-napthalimide
A R Katritzky1, S Ozcan, E Todadze
1Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA. katritzky@chem.ufl.edu
Bioorganic & Medicinal Chemistry Letters
|August 3, 2010
Abstract:
The synthesis and fluorescence properties of new highly fluorescent nucleosides are reported. 6-Chloro-2,3-napthalimides activated with benzotriazole and chlorine label nucleosides quickly and efficiently in yields of 70-82%: the products exhibit quantum efficiencies of 10-94% in solvents of diverse polarity.

